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KMID : 0861220160180010018
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Journal of the Korean Society Clinical Neurophysiology
2016 Volume.18 No. 1 p.18 ~ p.20
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Myelin Water Fraction MRI in a Case of Clinically Probable Amyotrophic Lateral Sclerosis
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Yang Ji-Won
Lee Jong-Ho
Kim Eung-Yeop
Shin Dong-Hoon
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Abstract
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Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron degenerative disease that clinically manifests both upper and lower motor neuron signs. However, it is unknown where and how the motor neuron degeneration begins, and conflicting hypotheses have been suggested. Recent advanced radiological techniques enable us to look into ALS neuropathology in vivo. Herein, we report a case with upper motor neuron-predominant ALS in whom the results of brain magnetic resonance imaging (MRI) and myelin water fraction MRI suggest axonal degeneration.
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KEYWORD
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Amyotrophic lateral sclerosis, Magnetic resonance imaging, Pathology
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